Bioavailability of Praziquantel Increases with Concomitant Administration of Food
- 1 October 2000
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (10) , 2903-2904
- https://doi.org/10.1128/aac.44.10.2903-2904.2000
Abstract
In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.Keywords
This publication has 10 references indexed in Scilit:
- Dietary Fat Level and Short-Term Effects of a High-Fat Meal on Food Intake and MetabolismAnnals of Nutrition and Metabolism, 1998
- Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimenAntimicrobial Agents and Chemotherapy, 1997
- Pharmacokinetic interaction between praziquantel and albendazole in Sudanese menPathogens and Global Health, 1994
- Sensitive high-performance liquid chromatographic assay for praziquantel in plasma, urine and liver homogenatesJournal of Chromatography B: Biomedical Sciences and Applications, 1993
- Pharmacokinetics of praziquantel in healthy volunteers and patients with schistosomiasisTransactions of the Royal Society of Tropical Medicine and Hygiene, 1990
- Plasma levels of praziquantel decrease when dexamethasone is given simultaneouslyNeurology, 1987
- Food effects on propranolol systemic and oral clearance: Support for a blood flow hypothesisClinical Pharmacology & Therapeutics, 1986
- Effect of carbohydrates on estimated hepatic blood flowClinical Pharmacology & Therapeutics, 1984
- Effect of food on hepatic blood flow: Implications in the “food effect” phenomenonClinical Pharmacology & Therapeutics, 1983
- Statistical moments in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1978