Study of the dynamic behavior of the chemostat system
- 1 July 1967
- journal article
- research article
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 9 (3) , 375-386
- https://doi.org/10.1002/bit.260090310
Abstract
This paper deals with a theoretical study on the dynamic, character of the chemostat system. It. is primarily based on the Monod model for growth limitation, although certain more complex models are considered. Since the Monod model is described in terms of two variables, an analysis by use of a phase plane plot will show the various possible types of behavior theoretically expected for transient conditions of the system. In this paper it will be shown that the chemostat system might show an overshoot (or an underswing) with respect to changes in cell and substrate concentrations, depending on the extent to which the system might be disturbed from steady‐slate conditions. Other types of transient behavior ran also be expected when one of the system parameters such as dilution rate or input substrate concentration is disturbed in a stepwise manner. The simple Monod chemostat model was found never to oscillate in either a damped or a sustained manner as has been experimentally reported. Discussion is included about the transient behavior of other chemostat models such as that involving a variable yield coefficient, i.e., including the effect of cell maintenance requirements.This publication has 2 references indexed in Scilit:
- Measurement of Unsteady State Growth Rates of Micro-OrganismsNature, 1965
- THE MAINTENANCE REQUIREMENT OF ESCHERICHIA COLIAnnals of the New York Academy of Sciences, 1963