The Effect of Endocrine Treatment on Advanced Breast Cancer in Japan

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Abstract
The results of ablative endocrine treatment in patients with advanced breast cancer in Japan have been reviewed retrospectively. Data from breast cancer patients who received endocrine therapy have been collected from eight centers. The total number of patients receiving ablative endocrine therapy was 288; of these, 37 were excluded because the available data were inadequate. The criteria of response were the same as those described by Hayward (1966) and Taylor (1966), in that success was considered as objective remission of all metastatic lesions for a period of longer than six months. By this definition, the success rate from bilateral oophorectomy was 27.1% while that from adrenalectomy varied from 30.6% to 38.2% depending on the method of operation used. The mean survival time following operation in successful cases varied between 31.6 and 39.8 months. Patients with pulmonary metastases survived longer than patients with soft tissue lesions or those with skeletal secondaries. The effect of testosterone propionate on advanced breast cancer seems to be in the range of response reported in the U.S.A. Japanese breast cancer patients responded well to fluoxymesterone administration but it is too early to be certain of the overall results of androgen therapy in these women.

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