Range of Histologic Variation in Clinically Normal Gingiva

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Abstract
Biopsies (38) taken from clinically normal mouths illustrated the range of histologic difference within a non-pathologic standard. Epithelial variations found include differences in the total tnick-ness, an almost predominant parakeratosis rather than "skin-type** keratin on the surface, and the normal presence of varying degrees of intracytoplasmic vacuolization. Most striking sub-mucosal variations included sparse to heavy vascularity, varying densities of chronic inflammatory exudate, broad range of variation in extent of polymerization of collagen matrix, fiber bundles ranging from reticular to dense and almost hyalinized. Extension of the rigid definition of gingival normality to include a wider range of histologic variation seems desirable in order to clarify concepts of gingival pathology.

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