A double‐blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome

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Abstract
A double‐blind randomized crossover study of 7.5 mg bromocriptine at bedtime versus placebo was conducted in 30‐day phases (with a 2‐week washout period between phases) in 6 patients with idiopathic restless legs syndrome. Five patients experienced partial subjective improvement in restlessness and paresthesias on bromocriptine as opposed to placebo and expressed a desire to continue on the medication. On bromocriptine, the patients showed polysomnographically a mean Decemberrease of 43% from control and a mean Decemberrease of 57% from placebo in the number of periodic movements of sleep per hour of sleep (p < 0.025). Two of 3 patients with abnormally Decemberreased total sleep time and sleep efficiency showed an improvement in these measures on therapy. The dopamine agonist bromocriptine may be a useful therapy in some patients with restless legs syndrome.