Studies in Sickle-Cell Anemia
- 1 February 1958
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Journal of Diseases of Children
- Vol. 95 (2) , 157-163
- https://doi.org/10.1001/archpedi.1958.02060050159008
Abstract
Sickle-cell anemia (SCA) was first described in 1910,1but involvement of osseous tissue in this disease was not reported until 1924, when Graham2autopsied a 30-year-old man and found the marrow cavity reduced in size and at one point obliterated. In 1927, Cooley3described a skull which on roentgenography showed widening of the diploic spaces, a thin or absent outer table, and parallel lines radiating from the inner table. Similar roentgenograms have subsequently been reported in other patients with SCA. More recently, there have been additional publications4-32on bone involvement in SCA, but few of these report aseptic necrosis of the femur or the humerus. This paper presents two additional cases of aseptic necrosis of the femur in children with SCA. One of these cases also showed aseptic necrosis of the head of the humerus. Report of Cases Case1.—A 14-year-old Negro boy was hospitalized onKeywords
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