P2 receptors in macrophage fusion and osteoclast formation
Open Access
- 6 February 2007
- journal article
- research article
- Published by Springer Nature in Purinergic Signalling
- Vol. 3 (1-2) , 53-57
- https://doi.org/10.1007/s11302-006-9036-9
Abstract
Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X7, are involved in this process, although P2X7 is not absolutely required for fusion because P2X7-null mice form multinucleated osteoclasts. Extracellular ATP may be an important regulator of macrophage fusion.Keywords
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