Expression of the candidate invasion suppressor gene, nm23, in human brain tumors
- 1 September 1998
- journal article
- Published by Wiley in Neuropathology
- Vol. 18 (3) , 315-320
- https://doi.org/10.1111/j.1440-1789.1998.tb00121.x
Abstract
The nm23 genes encode a family of multifunctional proteins with well‐documented enzymatic and DNA‐binding functions. There are five isoforms of nm23 of which two, nm23‐H1 and nm23‐H2 have been widely studied within the context of metastasis suppression in a large variety of human cancers. However, the role of nm23 in mediating the invasive behavior of central nervous system neoplasms remains to be clarified. In the present study, we provide evidence that nm23 may suppress the invasive phenotype in primary human brain tumors.Keywords
This publication has 29 references indexed in Scilit:
- A 16-kDa Protein Functions as a New Regulatory Protein for Hsc70 Molecular Chaperone and Is Identified as a Member of the Nm23/Nucleoside Diphosphate Kinase FamilyJournal of Biological Chemistry, 1997
- Expression of humannm23-H1 andnm23-H2 proteins in hepatocellular carcinomaCancer, 1994
- Evaluation of the expression levels of nm23-h1 mRNA in primary breast cancer, benign breast disease, axillary lymph nodes and normal breast tissuePathology, 1994
- Expression ofnm23-Hl andnm23-H2 Proteins in Prostate CarcinomaJapanese Journal of Cancer Research, 1993
- Reduced expression of nm23‐H1, but not of nm23‐H2, is concordant with the frequency of lymph‐node metastasis of human breast cancerInternational Journal of Cancer, 1993
- Reduced Expression of nm23 Is Associated with Metastasis of Human Gastric CarcinomasJapanese Journal of Cancer Research, 1993
- Immunohistochemical Analysis of Expression of nm23-H1/Nucleoside Diphosphate Kinase in Human Thyroid Carcinomas: Lack of Correlation Between Its Expression and Lymph Node MetastasisThyroid®, 1993
- Expression in Human Hepatocellular Carcinoma of Nucleoside Diphosphate Kinase, a Homologue of the nm23 Gene ProductJNCI Journal of the National Cancer Institute, 1992
- Evidence for a Novel Gene Associated With Low Tumor Metastatic PotentialJNCI Journal of the National Cancer Institute, 1988