DOSAGE IN THE THERAPY OF CARDIOVASCULAR DISEASE

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Abstract
The problem of dosage is important in therapeutics and has not received the attention it deserves. In connection with clinical studies in the Department of Pharmacology, the staff has long been interested in the application of pharmacologic principles in drug therapy. Medical practice has been backward in applying knowledge gained in the experimental laboratories. It has been emphasized by my associate, Dr. Harry Gold, that a large proportion of the failures in drug therapy result not so much from the choice of the wrong drug as from the incorrect use of the right drug.1Either the dose is too small or too large, or the frequency of administration does not meet the requirements of the particular situation. There are many examples in current therapeutic practice of the failure to utilize well established knowledge regarding the behavior of drugs in the body, some of which will be mentioned later. The

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