Finnish Experiences with Carbamazepine (Tegretol ®) in the Treatment of Acute Withdrawal Symptoms in Alcoholics

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Abstract
The drinking problem in Finnish society is far from uncommon and has worsened with an increase in economic welfare. In a multicenter trial 105 male out-patients, aged 20-60 yr, who had voluntarily sought treatment for alcohol withdrawal symptoms at 5 Finnish A-clinics or alcoholism treatment centers were entered into the study. The patients were randomly allocated to 2 treatments, carbamazepine [CBZ] and placebo, a double-blind technique being employed. CBZ may be an alternative treatment in the ambulatory treatment of alcohol withdrawal symptoms particularly because: it has no interaction with alcohol; its metabolization in the liver of alcoholics is not affected; it has no dependence-inducing properties; and it seems to decrease the target of alcohol withdrawal symptoms and to speed up the return of ability of work. The mechanism of action still remains to be determined.

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