Hepatic Impairment During the Intake of Contraceptive Pills: Clinical Trial with Postmenopausal Women

15 August 1964

journal article
letter
Published by BMJ in BMJ

Vol. 2 (5406) , 426-427
https://doi.org/10.1136/bmj.2.5406.426

Abstract

Seven postmenopausal women were treated for 28 days with a contraceptive drug. This clearly resulted in hepatic dysfunction in every patient, as judged by elevation of serum transaminase levels. The progestogen component of the drug was without effect in the 2 patients studied, and in 1 out of 3 cases treated with the estrogen component of the drug changes in hepatic function similar to those produced by the whole drug were observed.

Keywords

ALANINE AMINOTRANSFERASE
ASPARTATE AMINOTRANSFERASE
BILIRUBIN
BLOOD ALKALINE PHOSPHATASE
BLOOD CHEMICAL ANALYSIS
CLINICAL RESEARCH
CONTRACEPTIVES, ORAL
ENZYME TESTS
ETHINYL ESTRADIOL
HEPATITIS, TOXIC
LIVER FUNCTION TESTS
PROGESTATIONAL HORMONES
SULFOBROMOPHTHALEIN
TOXICOLOGIC REPORT

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