Sample size tables for exact single‐stage phase II designs
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- 5 March 2001
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 20 (6) , 859-866
- https://doi.org/10.1002/sim.721
Abstract
Tables for single‐phase II trials based on the exact binomial distribution are presented. These are preferable to those generated using Fleming's design, which are based on the normal approximation and can give rise to anomalous results. For example, if the upper success rate is accepted, the lower success rate, which the trial is designed to reject, may be included in the final confidence interval for the proportion being estimated. Copyright © 2001 John Wiley & Sons, Ltd.Keywords
This publication has 6 references indexed in Scilit:
- Optimal three-stage designs for phase II cancer clinical trialsStatistics in Medicine, 1997
- An optimal three‐stage design for phase II clinical trialsStatistics in Medicine, 1994
- Optimal two-stage designs for phase II clinical trialsControlled Clinical Trials, 1989
- Whole-body hyperthermia in cancer therapy: a report of a phase I–II studyEuropean Journal of Cancer and Clinical Oncology, 1983
- One-Sample Multiple Testing Procedure for Phase II Clinical TrialsPublished by JSTOR ,1982