Dendritic cells and humoral immunity in humans
Open Access
- 23 March 2010
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 88 (4) , 376-380
- https://doi.org/10.1038/icb.2010.28
Abstract
Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14+ dermal DCs, cytotoxic T‐cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4+ T cells associated with aiding B‐cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.Keywords
Funding Information
- National Institutes of Health (P01 CA084514, U19 AI057234, U19 AI082715, R01 CA089440, CA078846)
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