The clearance of Xenon‐133 following its parenchymal injection: a rapid method for estimating functional liver blood‐flow

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Abstract
Summary. Portal venous flow, total hepatic blood‐flow and hepatic artery flow were measured in healthy dogs by electromagnetic flowmetry and a double indicator dilution technique. Functional liver blood‐flow was measured by the double indicator dilution technique. Functional hepatic blood‐flow did not correlate with portal venous flow, total hepatic blood‐flow or hepatic artery flow, measured by either electromagnetic flowmetry or a double indicator dilution technique. There was a good correlation (r=0.83, P<0.001) between functional hepatic blood‐flow and liver blood‐flow, measured by the clearance of Xenon‐133 injected directly into the liver parenchyma. It is concluded that the clearance of Xenon‐133, injected directly into the liver parenchyma, is a rapid and simple method for measuring functional hepatic blood‐flow.