Renal vascular passage of red blood cells and plasma: derivation of transfer functions

Publisher Website
Google Scholar
Abstract
Canine renal vascular RBC and plasma transit was studied with 51cr-tagged RBC''s and 2 plasma labels of different particle size: indo-cyanine green (IG) and microaggregated RISA (MA131I). input (aortic) and output (renal vein) curves were recorded after central injection of IG and 1 of the radioactive indicators. Recovery and transit time of plasma labels indicate that IG describes an intravascular volume. The difference between appearance time ([DELTA] AT) and mean transit time ([DELTA] MCT) were taken as indices of dispersion. IG and 51Cr RBC curves revealed accelerated cell transit with less dispersion than plasma. [DELTA] AT and [DELTA] MCT were used to derive transfer functions. Results suggest that renal flow is comparable to that through a single conduit with a pattern intermediate between that expected from laminar and "bulk" flow. Cell separation or slow plasma component (medullary flow) was not apparent. Studies using slug aortic injection with renal vein sampling indicate that mean transit time may be estimated but information on the distribution of transit times is not consistent with preformed curve studies.

This publication has 15 references indexed in Scilit: