Effeets of folie aeid on phenytoin kineties in healthy subjeets
- 1 September 1978
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 24 (3) , 294-297
- https://doi.org/10.1002/cpt1978243294
Abstract
Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers DPH serum levels without significantly modifying its bound fraction and inereases the rate of DPH and meta-hydroxydiphenylhydantoin excretion in urine.This publication has 3 references indexed in Scilit:
- Depression of parahydroxylation of diphenylhydantoin by antituberculosis chemotherapyNeurology, 1966
- Subnormal Serum Folate and Macrocytosis Associated with Anticonvulsant Drug TherapyBlood, 1964
- THE RENAL EXCRETION OF FOLIC ACID*Journal of Clinical Investigation, 1963