The Effect of Terramycin on the PR8 Strain of Influenza a Virus in Chick Embryos and Mice

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Abstract
Summary: Terramycin, inoculated in high concentrations into either the yolk sac or the allantoic cavity, was found to inhibit the PR8 infection of the chick embryo when administered 1–3 hours before, or up to 1 hour after, the inoculation of 10 to 100 ID50 of the virus. Partial protection could be obtained against 500, but not against 1000, ID50 of the virus or by delaying therapy for 3, but not for 24, hours. When tested in concentrations comparable to those found in ovo, the antibiotic did not inactivate the virus in vitro. Concentrations of terramycin comparable to those found in ovo neither prevented the living virus from agglutinating RBC nor prevented the RBC from being agglutinated by the virus. Its presence in the hemagglutination system did not alter the titre of the virus. Oral, intravenous, or intranasal administration of terramycin did not influence the course of infection in mice induced by 25–50 LD50 of the PR8 strain.

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