Rabies Viruses Increase in Virulence When Propagated in Neuroblastoma Cell Culture
- 10 March 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4333) , 1072-1075
- https://doi.org/10.1126/science.628831
Abstract
Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.This publication has 25 references indexed in Scilit:
- Neurotransmitter metabolism in murine neuroblastoma cellsLife Sciences, 1976
- Expression of the neuron‐specific protein, 14‐3‐2, and steroid sulfatase in neuroblastoma cell hybridsJournal of Cellular Physiology, 1974
- Expression of neuronal phenotypes in neuroblastoma cell hybridsDevelopmental Biology, 1974
- Correlation between TS phenotype and pathogenicity of some animal virusesArchiv für die gesamte Virusforschung, 1973
- Virulence of a temperature-sensitive mutant of western equine encephalitis virusArchiv für die gesamte Virusforschung, 1972
- Responses of neuroblastoma cells to iontophoretically applied acetylcholineJournal of Cellular Physiology, 1971
- Temperature-Sensitive Mutants of Influenza Virus. I. Behavior in Tissue Culture and in Experimental AnimalsThe Journal of Infectious Diseases, 1971
- Encephalitis in Newborn Hamsters after Intracerebral Injection of Attenuated Human Measles VirusNature, 1970
- Attenuation of foot-and-mouth disease virus by chemical meansArchiv für die gesamte Virusforschung, 1970
- Small-scale Trial with Sabin Attenuated Type 1 Poliovirus Vaccine in a Semi-closed CommunityBMJ, 1962