Treatment of Severe Ocular-Surface Disorders with Corneal Epithelial Stem-Cell Transplantation

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Abstract
Conditions that destroy the limbal area of the peripheral cornea, such as the Stevens–Johnson syndrome, ocular pemphigoid, and chemical and thermal injuries, can deplete stem cells of the corneal epithelium. The result is scarring and opacification of the normally clear cornea. Standard corneal transplantation cannot treat this form of functional blindness.