Spin‐echo 1H NMR detected response of ergothioneine to oxidative stress in the intact human erythrocyte
- 1 February 1988
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 6 (2) , 217-223
- https://doi.org/10.1002/mrm.1910060210
Abstract
Human erythrocytes were subjected to oxidative stress using arsenicals. The study is a model for thiol-related redox processes observed in the etiology of diseases such as rheumatoid arthritis. Spin-echo NMR spectroscopy of the living cell was used to monitor the cellular biochemistry. Oxidation of glutathione and the first demonstrated response of ergothioneine to a chemical stimulus in a cell were observed. The reversible nature of the ergothioneine response is interpreted as an environmental rather than a chemical change.This publication has 19 references indexed in Scilit:
- A 1H spin echo NMR study of the HeLa tumour cellFEBS Letters, 1987
- Early and late changes in sulphydryl group and copper protein concentrations and activities during drug treatment with aurothiomalate and auranofin.Annals of the Rheumatic Diseases, 1986
- Changes in glutathione in intact erythrocytes during incubation with penicillamine as detected by 1H spin-echo NMR spectroscopyBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1986
- In search of a physiological function for L-ergothioneineMedical Hypotheses, 1985
- The reaction of methylarsenicals with thiols: Some biological implicationsJournal of Inorganic Biochemistry, 1984
- A proton nuclear magnetic resonance study of the binding of methylmercury in human erythrocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1982
- N.m.r. studies of red cellsPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1980
- Spin-echo Fourier transform nuclear magnetic resonance spectroscopyAnalytical Chemistry, 1979
- Human erythrocyte metabolism studies by 1H spin echo NMRFEBS Letters, 1977
- Über den jetzigen Stand der ChemotherapieEuropean Journal of Inorganic Chemistry, 1909