Synthesis and Biological Activity of Bromolignans and Cyclolignans
- 1 January 1993
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 326 (7) , 421-426
- https://doi.org/10.1002/ardp.19933260709
Abstract
Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows antiviral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.Keywords
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