IMMUNOGLOBULIN ALLOTYPES ARE NOT INVOLVED IN SYSTEMIC AMYLOIDOSIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 12  (4) , 742-746
Abstract
To evaluate the role of immunoglobulin (Ig) allotypes in the pathogenesis of amyloidosis, 8 Gm allotypes and the Km 1 allotype were determined in the sera of patients with amyloid AL (n=27) and amyloid AA (n=43). As controls we selected normal individuals (n=204), 2 patients groups with multiple myeloma (both n=40) and patients with rheumatoid arthritis (n=71) and Crohn''s disease (n=47). Our results clearly show that Ig allotypes are not involved in the development of amyloidosis. Our results indicate that the Km 1 allotypic marker is associated with RA.