Two-photon tissue imaging: seeing the immune system in a fresh light
Top Cited Papers
- 1 November 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 2 (11) , 872-880
- https://doi.org/10.1038/nri935
Abstract
Many lymphocyte functions, such as antigen recognition, take place deep in densely populated lymphoid organs. Because direct in vivo observation was not possible, the dynamics of immune-cell interactions have been inferred or extrapolated from in vitro studies. Two-photon fluorescence excitation uses extremely brief (in vivo setting and to reveal in detail the cellular collaborations that underlie the immune response.Keywords
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