Synthesis of single isomers (E or Z) of unsaturated carboxylic acids by the Horner-Wittig reaction
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 1799-1807
- https://doi.org/10.1039/p19880001799
Abstract
Alkyl(diphenyl)phosphine oxides (5) are used to synthesize pure E or Z isomers of unsaturated acids. The keto acids (10), made by two routes, are reduced to hydroxy acids whose crystalline lactones (12) can be separated and purified. Stereospecific elimination of Ph2PO2 – gives the unsaturated acids.This publication has 0 references indexed in Scilit: