Steps Toward Gene Therapy: 1. The Initial Trials
- 15 November 1995
- journal article
- review article
- Published by Taylor & Francis in Hospital Practice
- Vol. 30 (11) , 33-40
- https://doi.org/10.1080/21548331.1995.11443286
Abstract
Hopes for correcting the instruction tape in patients with genetic disease are being intensively explored. Initial efforts centered on monogenic immunodeficiency states, but in a pattern not wholly expected by researchers, the “acquired genetic diseases” of cancer and AIDS account for most ongoing clinical trials. Experience with adenosine deaminase deficiency shows the difficulties encountered in creating practical gene therapies.Keywords
This publication has 6 references indexed in Scilit:
- Development of Gene Therapy for Immunodeficiency: Adenosine Deaminase DeficiencyPediatric Research, 1993
- Gene transfer into hematopoietic stem cellsCancer, 1991
- Lymphocytes as cellular vehicles for gene therapy in mouse and man.Proceedings of the National Academy of Sciences, 1991
- Development of immunologic functions after bone marrow transplantation in 33 patients with severe combined immunodeficiencyBlood, 1989
- Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer.Proceedings of the National Academy of Sciences, 1986
- Prospects for Human Gene TherapyScience, 1984