Diagnostic Validity of the Dementia Questionnaire for Alzheimer Disease

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Abstract
NUMEROUS GENETIC determinants and susceptibility factors for Alzheimer disease (AD) and other dementias have been described.1,2 Linkage studies have contributed substantially to this increased knowledge.3,4 Such studies depend on the availability, accuracy, and completeness of clinical diagnoses for multiple members of a family, some of whom may be unavailable for clinical examination. To facilitate the ascertainment of more complete pedigrees, several instruments have been developed to help generate "remote" neurologic diagnoses, that is, to assign specific diagnoses when the subjects are unavailable for examination.