Preparation of Succinyl Neocarzinostatin
Open Access
- 1 March 1974
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 5 (3) , 354-355
- https://doi.org/10.1128/aac.5.3.354
Abstract
All amino groups in a proteinous antitumor antibiotic, neocarzinostatin, were reacted with succinic anhydride yielding bis- N -succinyl neocarzinostatin which retained biological activity in vitro against human cell lines and a bacterium. Amino groups in neocarzinostatin do not appear to play an important role in the activity.Keywords
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