Experimental Myocardial Infarction in Dogs

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Abstract
A closed chest technique for production of myocardial infarction in dogs is described. After isolation of the left carotid artery, selective coronary cineangiography is performed. A guide wire is then inserted into the catheter and advanced into the circumflex or anterior descending branch of the left coronary artery. The catheter is temporarily removed. A specially designed, siliconized, stainless steel cylinder is then inserted over the guide wire. The catheter is reinserted and is used to push, direct, and lodge the stainless steel cylinder into the anterior descending or the circumflex artery. The dogs are heparinized before, and for 3 days subsequent to, constriction. Ventricular arrhythmias are treated with procainamide. Coronary cineangiograms and serial electrocardiograms are obtained after coronary artery constriction. This technique provides an accurate model for research in the field of myocardial infarction.

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