Prevention of tissue damage: Inhibition of Myeloperoxidase mediated inactivation of α1 inhibitor by N-acetyl cysteine, Glutathione, and Methionine

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Abstract
The ability of the sulphur compounds, N-acetyl cysteine, Methionine, and Glutathione to prevent inactivation of α1 inhibitor by Myeloperoxidase-H2O2-Cl−-system was investigated in vitro with purified components. The Myeloperoxidase system, or its main product HOCl by itself, readily abrogated the ability of α1 inhibitor to inhibit elastase. This inactivation of α1 inhibitor was effectively prevented by micromolar concentrations of N-acetyl cysteine, Methionine and reduced Glutathione, whereas oxidized Glutathione was much less effective. These results indicate that the sulphydryl compounds work as scavengers of the products of the Myeloperoxidase system, and might be useful in inflammatory disorders, to prevent tissue damage inflicted by this system.