The genetics of schizophrenia: a reassessment using modern criteria

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Abstract
Two reasons for reassessing familial transmission of schizophrenia are presented: recent major changes in diagnostic criteria and methodological weaknesses of older studies. A study of this subject employed narrowly defined, operational research criteria; prospective proband selection; semistructured family interviews; and blind, independent diagnoses of probands and relatives. For 30 schizophrenic probands there was an age-corrected morbidity risk in 1st-degree relatives of 1.61%, a figure that would only support familial transmission if the true population prevalence of schizophrenia were .ltoreq. 0.2%. The case for familial transmission of narrowly defined schizophrenia is weak and alternate hypotheses are suggested.

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