The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90β gene by interleukin-6 but have opposite effects on its inducibility by heat shock
- 15 February 1998
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 330 (1) , 189-195
- https://doi.org/10.1042/bj3300189
Abstract
The levels of the 90 kDa heat-shock protein (hsp90) and the activity of the hsp90β gene promoter are increased in response to treatment by interleukinThis publication has 28 references indexed in Scilit:
- Regulation of Expression of the Interleukin 6 Gene: Structure and Function of the Transcription Factor NF‐IL6Published by Wiley ,2007
- IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral InfectionImmunological Reviews, 1992
- A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.Proceedings of the National Academy of Sciences, 1992
- IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBPCell, 1990
- A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.The EMBO Journal, 1990
- Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6.The EMBO Journal, 1989
- Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.Proceedings of the National Academy of Sciences, 1989
- The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6.The EMBO Journal, 1989
- CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elementsNucleic Acids Research, 1987
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976