Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"
Open Access
- 9 February 2007
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5813) , 766
- https://doi.org/10.1126/science.1135047
Abstract
Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein–coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.Keywords
This publication has 3 references indexed in Scilit:
- GPR39 Signaling Is Stimulated by Zinc Ions But Not by ObestatinEndocrinology, 2007
- Obestatin does not activate orphan G protein-coupled receptor GPR39Biochemical and Biophysical Research Communications, 2006
- Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food IntakeScience, 2005