EFFECT OF ANTIBIOTICS ON MUCOID STRAINS OF PSEUDOMONAS-AERUGINOSA

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  • 1 January 1979
    • journal article
    • research article
    • Vol. A130  (3) , 315-330
Abstract
The susceptibility to 18 antibiotics of 47 mucoid strains was compared to 71 fried-egg strains of Pseudomonas aeruginosa. The minimal inhibitory concentration was determinated by agar dilution method. The mucoid strains were more sensitive to antibiotics than the fried-egg strains. The more effective antibiotics were carbenicillins, aminoglycosides, colistin and tetracyclines. This drug susceptibility of mucoid strains was heterogeneous. The results of a statistical analysis demonstrated that the strains of P. aeruginosa were distributed into 2 classes: a 1st class clustered very sensitive strains to most antibiotics and a 2nd class clustered more resistant strains. The mucoid strains were included almost equally into the 2 classes (respectively, 45% and 55%). The fried-egg strains were more homogeneous, since 89% of these strains were in the resistant class. The antibiotics which distinguished the best between the 2 classes were tobramycin, netilmicin, amikacin, colistin and tetracyclines. The phenotypes and associations of resistances were studied.