Regulation of Fructose 1,6-Bisphosphatase by Histidine under Gluconeogenic Conditions
- 1 June 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (6) , 2166-2168
- https://doi.org/10.1073/pnas.71.6.2166
Abstract
Fructose 1,6-bisphosphatase (EC 3.1.3.11) requires a free divalent metal and a metal chelate for optimum activity in the neutral pH range. The latter requirement can be satisfied by histidine, which appears to function as the chelating metabolite in vivo. Under fasting conditions, the concentrations of histidine in rabbit liver vary in the range required for activation of fructose bisphosphatase, and the enzyme itself is modified so that it becomes more responsive to histidine.Keywords
This publication has 14 references indexed in Scilit:
- Changes in Activity and Molecular Properties of Fructose 1,6-Bisphosphatase During Fasting and RefeedingProceedings of the National Academy of Sciences, 1974
- The role of tryptophan in neutral fructose diphosphataseBiochemical and Biophysical Research Communications, 1974
- Changes in Rabbit-Liver Lysosomes and Fructose 1,6-Bisphosphatase Induced by Cold and FastingProceedings of the National Academy of Sciences, 1973
- Conversion of Neutral to Alkaline Liver Fructose 1,6-Bisphosphatase: Changes in Molecular Properties of the EnzymeProceedings of the National Academy of Sciences, 1973
- Activation of rabbit kidney fructose diphosphatase by Mg-EDTA, Mn-EDTA and Co-EDTA complexesArchives of Biochemistry and Biophysics, 1973
- Activation of rabbit muscle fructose diphosphatase by EDTA and the effect of divalent cationsArchives of Biochemistry and Biophysics, 1972
- Rabbit liver fructose 1,6-diphosphatase. Properties of the native enzyme and their modification by subtilisinArchives of Biochemistry and Biophysics, 1972
- The effect of starvation and alloxan-diabetes on the contents of citrate and other metabolic intermediates in rat liverBiochemical Journal, 1968
- Reciprocal effects of carbon sources on the levels of an AMP-sensitive fructose-1,6-diphosphatase and phosphofructokinase in yeastBiochemical and Biophysical Research Communications, 1965
- FRUCTOSE 1, 6-DIPHOSPHATASE IN STRIATED MUSCLEBiochemical Journal, 1965