Combined Cis-Platinum and Radiation Therapy in Patients with Stages PT3 and PT4 Bladder Cancer: A Pilot Study

Abstract
A prospective study was done on 8 patients with advanced transitional cell carcinoma of the bladder to evaluate toxicity of an integrated treatment with cis-diamminedichloroplatinum (1.6 mg/kg body wt 3 times/wk) and 60 gray 60Co or 18 MeV photons. Local and systemic toxicity caused by this treatment schedule was minor. Late sequelae consisted of a contracted bladder in 1 patient. The rate of bladders free of tumor after a mean follow-up of 7.7 mo. was surprisingly high (6 of 8).