NEW PLACENTAL PROTEINS AND THEIR POTENTIAL DIAGNOSTIC-SIGNIFICANCE AS TUMOR-MARKERS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 2  (3) , 141-153
Abstract
Five new soluble human placental tissue proteins (PP8, PP9, PP10, PP11 and PP12) have been isolated purified and characterized. PP9 has the electrophoretic mobility of a .beta.1-globulin; the other 4 proteins are .alpha.1-globulins. The MW of these proteins range from 25,000-65,000 daltons. All are glycoproteins with carbohydrate contents ranging from 3.9-6.6%. The amino acid compositions of these proteins were determined. PP8 and PP9 are ubiquitous tissue proteins in that they occur in relatively high concentrations in almost all human tissues examined. PP10, PP11 and PP12 could not be detected in extracts of other human tissues and may be specific to the placenta. PP10-12 was shown to be present in tumor tissues by an immunoglobulin enzyme bridge (PAP) technique. These proteins may be useful as markers in oncology.