Copper(II)-catalysed hydrolysis of an unactivated amide. Application of the groves' rule to the hydrolysis of acrylamide
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1707-1709
- https://doi.org/10.1039/c39900001707
Abstract
Conjugate addition of N-benzyl-N′,N′-dimethylethylenediamine to acrylamide affords a chelating amide in which the amide carbonyl can coordinate to the bound metal only via a six-membered chelate; this compound demonstrates copper(II)-catalysed amide hydrolysis, in which each metal acts on at least five equivalents of substrate.Keywords
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