Effect of a coronary vasodilator drug (carbochromen) on blood flow and oxygen extraction in acute myocardial infarction

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Abstract
Blood flow was measured in acute myocardial infarcts in dogs using a 133Xenon clearance technique. Simultaneous sampling of blood from a vein draining the infarct enabled assessments to be made of oxygen extraction and consumption. Flow and consumption were also measured in normal areas of myocardium. Carbochromen, though increasing flow in normal areas of myocardium, failed to increase flow in the infarct but oxygen extraction and consumption were reduced.