Opposing Effects of the Polycation Hexadimethrine (Polybrene) on Normal and Leukemic Lymphocytes

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Abstract
The polycationic compound hexadimethrine has opposing effects on normal and leukemic murine lymphocytes. This polycation significantly stimulated the DNA-synthetic response of murine spleen cells to alloantigens, whereas, at the same concentration, proliferation of the leukemic cell line, L1210, was inhibited. Other polycations tested did not show this effect. The hexadimethrine had no inhibited effect on the rejection rate of histoincompatible skin grafts in mice. Low concentrations did inhibit the growth of the L1210 leukemia cells in DBA/2J mice.