Corpus callosotomy in children

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Abstract
For children of medical resistant epilepsy without resectable epileptogenic zone, corpus callosotomy and vagus nerve stimulation (VNS) therapy are the two commonly used palliative epilepsy surgeries that can be considered. Although their routes and mechanisms to control epilepsy are different, both surgeries have shown their efficacy in selected candidates. The most common candidates for palliative surgery are in infants and children with organic encephalopathic types of epilepsy including infantile spasms/West syndrome, Lennox–Gastaut syndrome (LGS), severe epilepsy with multiple independent spike foci (SE-MISF) and selected symptomatic partial epilepsy to relief seizures and to stabilize co morbidities (Hirsch and Arzimanoglou, Revue Neurologique [Hirsch E and Arzimanoglou A, Rev Neurol (Paris). 160 Spec No 1:5S210–S219, ( 2004 ); Ohtahara S and Yamatogi Y, J Clin Neurophysiol 20(6):398–407, ( 2003 ); Wheless JW and Epilepsia 45(Suppl 5):17–22, ( 2004 ); Trevathan E, J Child Neurol 17 Suppl 2:2S9–2S22, ( 2002 )].