Platelet-Activating Factor Modulates Interleukin-6 Production by Mouse Fibroblasts

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Abstract
We compared the effects of platelet-activating factor (PAF), interleukin-1β (IL-1β) and polyriboinositic-polyribocytidylic acid (poly-I:C) on IL-6 production by confluent L929 mouse fibroblasts. At concentrations above 1 μM, PAF dose-dependently enhanced IL-6 production; at 5 μM PAF this increase (72.7 ± 19.9 U/ml) was higher than that evoked by 100 U/ml IL-1β (5.7 ± 0.4 U/ml) or 50 μg/ml poly-I:C (39.3 ± 6.7 U/ml). The IL-6 production induced by 5 μM PAF was not inhibited by addition of the specific PAF antagonist BN 52021 (10 μM) to the incubation medium. These results demonstrate that, as this is the case for IL-1, PAF also modulates IL-6 production.

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