Neuroleptic Malignant Syndrome Responsive to Carbidopa/Levodopa
- 1 April 1987
- journal article
- case report
- Published by Wolters Kluwer Health in Clinical Neuropharmacology
- Vol. 10 (2) , 186-189
- https://doi.org/10.1097/00002826-198704000-00010
Abstract
A 31-year-old man with psychosis and neuroleptic-induced tardive dystonia developed neuroleptic malignant syndrome (NMS) while taking haloperidol. Muscle rigidity responded to dantrolene, but hyperthermia did not abate until therapy with carbidopa/levodopa was initiated, after which temperature varied in direct relationship to subsequent levodopa administration. This supports the role for central dopaminergic mechanisms in the pathogenesis of NMS.Keywords
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