Total synthesis of (−)-PA-48153C (pironetin) utilising l-quebrachitol as a chiral building block
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 11,p. 1043-1044
- https://doi.org/10.1039/a701404j
Abstract
The chiral and stereoselective synthesis of (-)-PA-48153C (pironetin) 1, a novel immunosuppressant, is described; the acyclic portion possessing four contiguous chiral centres in 1 was constructed stereoselectively from L-quebrachitol and the 2-pyranone moiety was prepared from L-malic acid.Keywords
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