HETEROPHILE SYSTEM IN HUMAN RENAL-TRANSPLANTATION .6. BIOLOGIC EFFECT OF HETEROPHILE (HT-A) AND NON-HETEROPHILE (HL-A) COMPATIBILITY ON ALLOGRAFT SURVIVAL

  • 1 January 1976
    • journal article
    • research article
    • Vol. 80  (1) , 14-21
Abstract
A series of 79 selected renal allografts was studied to determine the biologic importance of the heterophile (HT-A) locus and the relative effects of HT-A and nonheterophile (HL-A) loci on allograft survival. The results demonstrate that HT-A and HL-A combined compatibility yield good results, whereas HT-A and HL-A combined incompatibility yield poor results. HT-A incompatibility with any serologically determined HL-A incompatibilities give a 1 yr allograft survival of 34%, and with 2 or more HL-A incompatibilities the 1 yr survival rate is only 22%. Compatibility at 1 locus with incompatibility at the other yields intermediate results. Thus incompatibilities at both loci seem cumulative. The chief difference in the effect of incompatibility of the 2 loci is that HT-A incompatibility is decisive early, whereas HL-A effects are seen later. The HT-A system appears to be a major determinant of renal allografts success which needs to be taken into account in compatibility testing.

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