Reye's syndrome; diagnosis by muscle biopsy?

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Abstract
Three children with Reye''s syndrome are described. One child died, the 2nd had mild and transient illness and the 3rd had recurrent episodes. In all 3 children a muscle biopsy showed pronounced infiltration of the myofibers with fat microdroplets as shown by the oil red O stain and by EM examination. Needle biopsy of muscle may be a quick and safe aid to the diagnosis of Reye''s syndrome and may be preferable to liver biopsy in view of the pronounced tendency to bleed in Reye''s syndrome.