Pharmacokinetics and Pharmacodynamics of Fluoroquinolones
- 1 January 1999
- journal article
- review article
- Published by Springer Nature in Drugs
- Vol. 58 (Supplement) , 29-36
- https://doi.org/10.2165/00003495-199958002-00006
Abstract
The fluoroquinolones have moderate to excellent bioavailability, moderate to long elimination half-lives (50 to 98%) and volumes of distribution >1.5 L/kg. There is considerable variation in...Keywords
This publication has 38 references indexed in Scilit:
- Pharmacokinetics and pharmacodynamics of oral grepafloxacin in patients with acute bacterial exacerbations of chronic bronchitisJournal of Antimicrobial Chemotherapy, 1997
- Interaction study of lomefloxacin and ciprofloxacin with omeprazole and comparative pharmacokineticsAntimicrobial Agents and Chemotherapy, 1995
- Effect of an antacid containing magnesium and aluminum on absorption, metabolism, and mechanism of renal elimination of pefloxacin in humansAntimicrobial Agents and Chemotherapy, 1994
- Multiple-dose pharmacokinetics of sparfloxacin and its influence on fecal floraAntimicrobial Agents and Chemotherapy, 1994
- Pharmacokinetics and serum bactericidal titers of ciprofloxacin and ofloxacin following multiple oral doses in healthy volunteersAntimicrobial Agents and Chemotherapy, 1993
- In vitro antimicrobial activity of CP-99433 compared with other fluoroquinolonesDiagnostic Microbiology and Infectious Disease, 1993
- Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsisAntimicrobial Agents and Chemotherapy, 1993
- Inhibition of norfloxacin absorption by dairy productsAntimicrobial Agents and Chemotherapy, 1992
- Multicenter in vitro evaluation of lomefloxacin (NY-198, SC-47111), including tests against nearly 7,000 bacterial isolates and preliminary recommendations for susceptibility testingDiagnostic Microbiology and Infectious Disease, 1988
- Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistanceAntimicrobial Agents and Chemotherapy, 1987