Effect of Concentration of Oxygen on Occurrence of Pulmonary Tumors in Strain A Mice

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Abstract
The exposure of strain A mice to approximately 100 percent oxygen for 48 hours following the injection of dibenz[a,b]anthracene resulted in an increase in the number of induced pulmonary tumors, in confirmation of results published earlier. In addition, it was demonstrated that exposure of the mice to the high oxygen concentration for 48 hours, beginning 48 hours after the injection of the carcinogen, likewise increased the occurrence of tumors, but no increase in induced tumors occurred from exposure to the high oxygen concentration either immediately or 48 hours prior to the injection of the carcinogen. The exposure of strain A mice to 8 percent oxygen for 48 hours following the injection of dibenz[a,b]anthracene resulted in a decrease in the number of tumors induced with the carcinogen. Exposure of newborn strain A mice to approximately 100 percent oxygen for 48 hours did not alter the incidence of spontaneous pulmonary tumors.

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