STUDIES ON AUTO-DIGESTION

Publisher Website
Google Scholar
Abstract
Implantation of a piece of omentum into the intestinal lumen, which presents a ready surface of absorption to the bowel contents, e.g., trypsin, did not change the "antitryptic" titre. Thyro-parathyroidectomy, methyl-guanidine injections, and administration of croton oil, all possibly influencing intestinal permeability, have no effect on the "antitryptic" titre in normal and omental-implanted dogs. Injection of commercial trypsin solutions or pancreatic juice, either subcutaneously or intraperitoneally, and inoculation of whole pancreatic tissue, produce no change. Presence of increased amounts of other ferments occurring in septic and aseptic diseases, is equally without influence. Sera of chicken, duck, goose, and pigeon possess a positive "antitryptic" titre nearly equal to that of dogs. Earthworms on extraction in saline have marked "antitryptic" properties. It was concluded that trypsin does not act as an antigen and that the trypsin-inhibiting factor of serum is not an antibody, confirming work of Young, Opie, Jobling and others. The titre is not dependent on viscosity of sera, nor upon changes in surface tension produced by saponin. The "antitryptic" titre is perhaps the product of 2 components, a proteolytic ferment and a tryptic inhibitory substance. Survival of living tissue (omental implants) exposed to the action of trypsin does not depend upon immunization against the ferment, but on some unknown, perhaps local, factor.

This publication has 0 references indexed in Scilit: