Suppression of Early Rhesus Sensitization by Passive Anti‐D Immunoglobulin:Suppression of Early Rhesus Sensitization

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Abstract
Anti‐D immunoglobulin is an effective prophylactic against rhesus isoimmunization. It is generally regarded as ineffective once antibody production has developed though there have been a number of inconclusive reports suggesting it may suppress early sensitization. Anti‐D (100μg) was given after delivery of a rhesus (D) positive child to a rhesus (D) negative mother who was shown to have anti‐D antibodies at that time by five tests on two separate specimens in two different laboratories and by a weakly positive direct anti‐globulin test on the cord blood. In a further pregnancy with a rhesus (D) positive child no antibody was detected by multiple tests including enzyme technique.

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