Escherichia coli mazEF -Mediated Cell Death Is Triggered by Various Stressful Conditions
Open Access
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 186 (11) , 3663-3669
- https://doi.org/10.1128/jb.186.11.3663-3669.2004
Abstract
mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF -mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.Keywords
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